Syrian Hamster Sars Cov 2

Sars cov 2 isolates replicated efficiently in the lungs of hamsters causing severe pathological lung lesions following intranasal infection.

Syrian hamster sars cov 2. Here we assessed the replicative ability and pathogenesis of sars cov 2 isolates in syrian hamsters. The syrian hamster could be consistently infected by sars cov 2. Noncontact transmission of sars cov 2 in the syrian hamster model. Maximal clinical signs of rapid breathing weight loss histopathological changes from the initial exudative phase of diffuse alveolar damage with extensive apoptosis to the later proliferative phase of tissue repair airway and intestinal involvement with virus nucleocapsid protein expression high lung viral load and spleen.

Each group of six. Implications for disease pathogenesis and transmissibility. Each system contained 2 cages left and right separated by a polyvinyl chloride air porous partition. 16 5 mg kg and subsequent serial fourfold dilutions.

A sars cov 2 specific human neutralizing mab cc12 1 isolated from natural infection was administered at a starting dose of 2 mg per animal average. A the closed systems housing the hamsters were placed in the isolator in a biosafety level 3 laboratory. In addition microcomputed tomographic imaging revealed severe lung injury that shared characteristics with sars cov 2 infected human lung including. Simulation of the clinical and pathological manifestations of coronavirus disease 2019 covid 19 in golden syrian hamster model.

After sars cov 2 infection the hamsters show rapid breathing weight loss and diffuse alveolar damage with extensive apoptosis. Effective vaccines and therapeutics for sars cov 2 induced disease coronavirus disease 2019 covid 19 are urgently needed. Control animals received 2 mg of den3. We report the pathogenesis and transmissibility of the sars cov 2 in golden syrian hamsters.

Since sars cov 2 emerged in china it has spread rapidly around the world. We found that sars cov 2 isolates replicate efficiently in the lungs of syrian hamsters and cause severe pathological lesions in the lungs of these animals similar to commonly reported imaging. An electrically powered fan was. The syrian hamster could be consistently infected by sars cov 2.

5 a potent sars cov 2 rbd specific neutralizing mab protects against weight loss and lung viral replication in syrian hamsters. Immunohistochemistry demonstrated viral antigens in nasal mucosa bronchial epithelial cells and in. The pathogenicity and transmissibility of sars cov 2 in golden syrian hamsters resemble features of covid 19 in human patients suggesting that these hamsters could be used to model this disease.